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D-Chiro-Inositol vs Myo-Inositol: The 40:1 Ratio Explained

Short answer: Your body uses two forms of inositol, myo-inositol (dominant, supports egg quality and insulin signalling) and D-chiro-inositol (smaller amounts, insulin-related). Research favours combining them in a 40:1 ratio, mirroring the body's natural balance, too much D-chiro can be counterproductive.

The two inositols

  • Myo-inositol: the most abundant form; supports ovarian function and insulin response.
  • D-chiro-inositol: present in smaller amounts; involved in insulin signalling.

Why 40:1?

The body maintains roughly a 40:1 myo-to-D-chiro ratio in many tissues. Studies suggest this ratio supports cycles and ovulation best and that very high D-chiro alone may not help (and can hinder) egg quality.

Femme Flourish uses the studied 40:1 ratio rather than myo-inositol alone.

Frequently asked questions

Which inositol is best for PCOS?

The 40:1 myo-to-D-chiro combination has the strongest support.

Can you take too much D-chiro-inositol?

Possibly, high D-chiro alone may not benefit and could affect egg quality, which is why the ratio matters.

Is myo-inositol alone enough?

It is beneficial, but the 40:1 blend reflects the body's natural balance.

Education only, not medical advice. Not evaluated by the Medicines Control Council; not intended to diagnose, treat, cure or prevent any disease.

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