index

Inositol vs Metformin for PCOS: What's the Difference?

Short answer: Both inositol and metformin target insulin resistance in PCOS. Metformin is a prescription medication; inositol (especially myo + D-chiro in a 40:1 ratio) is a naturally occurring compound that's generally well tolerated with fewer digestive side effects. Many people use inositol first or alongside lifestyle changes.

How each one works

Metformin reduces glucose production and improves insulin sensitivity. Inositol acts as a messenger in insulin signalling and supports ovarian function, addressing similar pathways from a different angle.

How they compare

  • Type: metformin = prescription drug; inositol = supplement.
  • Tolerability: metformin can cause digestive side effects; inositol is usually gentler.
  • Evidence: both have research support for cycle regularity and insulin.

Which should you choose?

That's a conversation with your doctor, especially if you're already on metformin. The 40:1 inositol ratio is what is used in Femme Flourish.

Frequently asked questions

Can I take inositol and metformin together?

Many people do, but confirm with your healthcare provider first.

Is inositol as effective as metformin?

Research suggests comparable benefits for insulin and cycles for many people, with better tolerability. But individual results vary.

What ratio of inositol is best?

The 40:1 myo-to-D-chiro ratio mirrors the body's natural balance and is the most studied.

Education only, not medical advice. Not evaluated by the Medicines Control Council; not intended to diagnose, treat, cure or prevent any disease. Don't stop prescribed medication without medical guidance.

Verified